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- Title
Dynamic Ion Speciation during the Hydrolysis of Aryltrifluoroborates**.
- Authors
Omari, Isaac; Yunker, Lars P. E.; Penafiel, Johanne; Gitaari, Darlene; San Roman, Atzin; McIndoe, J. Scott
- Abstract
Organotrifluoroborates serve as coupling partners during transmetalation in the Suzuki–Miyaura reaction but require hydrolysis prior to the coupling reaction. Their anionic nature allows study of their hydrolysis by electrospray ionization mass spectrometry (ESI‐MS) through real‐time monitoring, complemented by pH analysis. The induction period varied according to the borates employed, and a dynamic series of equilibria for numerous ions was observed during hydrolysis. We found that the induction periods and reaction rates were sensitive to the R group of the borates, the shape of the reaction vessel, and stir rate.
- Subjects
ELECTROSPRAY ionization mass spectrometry; HYDROLYSIS; SUZUKI reaction; CHEMICAL speciation
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 11, p3812
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202004726