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- Title
Study of Oxidative Damage in Growing–Finishing Pigs with Continuous Excess Dietary Chromium Picolinate Intake.
- Authors
Gao-Yi Tan; Shan-Shan Zheng; Min-Hong Zhang; Jing-Hai Feng; Peng Xie; Jin-Ming Bi
- Abstract
Abstract Chromium picolinate (CrPic) is a popular nutritional supplement; however, its safety has been questioned as it may be a source of oxidative stress that induces genotoxicity. The current work investigated the effect of excessive CrPic intake on oxidative damage in growing–finishing pigs. Thirty castrated male pigs, weighing approximately 30 kg each, were randomly divided into five groups and fed a diet with 0, 200, 800, 1,600, 3,200 μg of Cr/kg feed as CrPic for 80 days (approximately the entire growing–finishing period). High CrPic dose significantly decreased superoxide dismutase activity in serum at 80 days as well as the catalase activity in kidney (p p > 0.05). These results suggested that long-term exposure to different doses of CrPic in feed did not increase the formation of biomarkers of oxidative damage in growing–finishing pigs. However, taking into account the changes of antioxidant enzymes activity, excessive dietary CrPic intake was not recommended in this study.
- Subjects
OXIDATIVE stress; CHROMIUM compounds; CHROMIUM in animal nutrition; SWINE physiology; SUPEROXIDE dismutase; DIETARY supplements
- Publication
Biological Trace Element Research, 2008, Vol 126, Issue 1-3, p129
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-008-8207-7