We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dalbergia odorifera Extract Ameliorates UVB-Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins.
- Authors
Ham, Sun Ah; Kang, Eun Sil; Yoo, Taesik; Lim, Hyun Ho; Lee, Won Jin; Hwang, Jung Seok; Paek, Kyung Shin; Seo, Han Geuk
- Abstract
Emerging evidence suggests that Dalbergia odorifera T. Chen (Leguminosae), an indigenous medicinal herb, has therapeutic potential. This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB-irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)-β1 in human dermal fibroblasts. In HR-1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF-β1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase-2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-3 in skin tissue exposed to UVB. These results suggest that the ethanol extracts prevent some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins.
- Subjects
DALBERGIA; PHYSIOLOGICAL effects of ultraviolet radiation; WRINKLE treatment; HERBAL medicine; EXTRACELLULAR matrix proteins
- Publication
Drug Development Research, 2015, Vol 76, Issue 1, p48
- ISSN
0272-4391
- Publication type
Article
- DOI
10.1002/ddr.21240