We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
BODIPY-based fluorescent chemosensor for phosgene detection: confocal imaging of nasal mucosa and lung samples from mouse exposed to phosgene.
- Authors
Kong, Ying-Ying; Sun, Tang-Qiang; Yu, Miao-Miao; Xia, Hong-Cheng
- Abstract
The improper use of phosgene, either as a chemical warfare agent or a leak during chemical production, causes significant risks to human life and property. Therefore, it is particularly important to develop a rapid and highly selective method for the detection of phosgene. In this article, a highly selective fluorescent sensor ONB with a BODIPY unit as a fluorophore and o-aminophenol as a reactive site was constructed for the selective and rapid detection of phosgene in solution. The ONB-containing nanofibers were sprayed onto a non-woven fabric by electrostatic spinning and cut into test films, which can be used well for the detection of gaseous phosgene. While, there were no reported bio-imaging applications for phosgene detection. In this work, nasal mucosa and lung samples from the mice exposed to gaseous phosgene after dropping the ONB solution through the nasal cavity achieved bio-imaging applications successfully.
- Subjects
PHOSGENE; CHEMICAL warfare agents; NASAL cavity; NONWOVEN textiles; LUNGS
- Publication
Analytical & Bioanalytical Chemistry, 2022, Vol 414, Issue 17, p4953
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-022-04120-5