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- Title
Bifunctional Chiral Agent Enables One‐pot Spontaneous Deracemization of Racemic Compounds.
- Authors
Su, Xin; Sun, Jie; Liu, Jiaqiang; Wang, Yaoguo; Wang, Jingkang; Tang, Weiwei; Gong, Junbo
- Abstract
A novel one‐pot deracemization method using a bifunctional chiral agent (BCA) is proposed for the first time to convert a racemate to the desired enantiomer. Specifically, chiral α, (α‐diphenyl‐2‐pyrrolidinemethanol) formed enantiospecific cocrystals with racemic dihydromyricetin, and used its own alkaline catalysis to catalyze the racemization between the (2R,3R)‐enantiomer and (2S,3S)‐enantiomer in solution, achieving a one‐pot spontaneous deracemization. This strategy was also successfully extended to the deracemization of three other racemic compound drugs: (R,S)‐carprofen, (R,S)‐indoprofen, and (R,S)‐indobufen. The one‐pot deracemization method based on the BCA strategy provides a feasible approach to address the incompatibility between cocrystallization and racemization reactions that are commonly encountered in the cocrystallization‐induced deracemization process and opens a new window to develop essential enantiomerically pure pharmaceutical products with atom economy.
- Subjects
RACEMIC mixtures; DERACEMIZATION; ENANTIOMERIC purity; RACEMIZATION; DOSAGE forms of drugs
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 22, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202402886