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- Title
One-Pot Synthesis of Sulfonamides and Sulfonyl Azides from Thiols using Chloramine-T.
- Authors
Maleki, Behrooz; Hemmati, Saba; Tayebee, Reza; Salemi, Sirous; Farokhzad, Yasaman; Baghayeri, Mehdi; Zonoz, Farrokhzad Mohammadi; Akbarzadeh, Elahe; Moradi, Rohollah; Entezari, Azam; Abdi, Mohammad Reza; Ashrafi, Samaneh Sedigh; Taimazi, Fereshteh; Hashemi, Majid
- Abstract
A convenient synthesis of sulfonamides and sulfonyl azides from thiols is described. In situ preparation of sulfonyl chlorides from thiols was accomplished by oxidation with chloramine-T (= N-chlorotosylamide= N-chloro-4-methylbenzenesulfonamide), tetrabutylammonium chloride (Bu4NCl), and H2O. The sulfonyl chlorides were then further allowed to react with excess amine or NaN3 in the same pot.
- Subjects
THIOL synthesis; SULFONAMIDES; SULFONYL azides; CHLORAMINES; AMINE synthesis
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 11, p2147
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200648