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- Title
Application of the fracture risk assessment tool (FRAX<sup>®</sup>) and determination of suitable cut-off values during primary screening in specific health check-ups in Japan.
- Authors
Nakatoh, Shinichi; Takemaru, Yuki
- Abstract
Specific health check-ups, which do not include osteoporosis screening, are conducted more frequently than periodic osteoporosis screening in Japan. In this study, we investigated the usefulness of the fracture risk assessment tool (FRAX ®) during specific health check-ups, evaluated the variations in its usefulness for 2 consecutive years, and determined FRAX ® cut-off values for osteoporosis screening. FRAX ® questionnaires were distributed to subjects who underwent specific health check-ups in 2009 and 2010 at Asahi-machi. Subjects who exhibited FRAX ® cut-off values of ≥10 % were advised to be screened at a medical institution. Bone mineral densities (BMDs) were measured in 201 subjects in 2009 and 105 subjects in 2010 after specific health check-ups, and treatment was initiated for 79 subjects in 2009 and 24 subjects in 2010. The number of subjects examined and the rate of treatment initiation following specific health check-ups were higher than those in subjects following periodic osteoporosis screening in 2009. However, the number and the rate following specific health check-ups dropped in 2010. According to receiver operating characteristic curves analyses, the sensitivity and specificity of FRAX ® to determine osteoporosis treatment were highest when the cut-off values were 8 % for men and 10.5 % for women. In conclusion, the combination of FRAX ® and specific health check-ups was more useful than periodic osteoporosis screening to narrow down the subjects and to motivate them to seek follow-up. Cut-off values for specific health check-up using FRAX ® should be approximately 8 % for men and 10.5 % for women
- Subjects
JAPAN; RISK factors of fractures; OSTEOPOROSIS diagnosis; MEDICAL screening; MEDICAL care; BONE density
- Publication
Journal of Bone & Mineral Metabolism, 2013, Vol 31, Issue 6, p674
- ISSN
0914-8779
- Publication type
Article
- DOI
10.1007/s00774-013-0457-6