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- Title
Action of mibefradil and lacidipine on the isolated human anterior tibial artery.
- Authors
Martinuč, Jana; Drevenšek, Gorazd; Budihna, Metka V.
- Abstract
In isolated human anterior tibial artery the effects of two different types of calcium channel antagonists, mibefradil (a selective T-type Ca2+ channel antagonist) and lacidipine (a 1,4 dihydropyridine Ca2+ channel antagonist, acting at L- and T-type, but binds preferentially at L-type Ca2+ channels) were compared. Both drugs reduced the contractions of isolated arteries induced by 60 mM KCl. The potency (IC50) of mibefradil was 6.5 μM and of lacidipine 82.4 nM. The potencies of both Ca2+ channel antagonists differed significantly (p<0.001 at 0.1 and 1 μM; p<0.01 at 10 μM). Lacidipine was 79-times more effective than mibefradil in reducing the vasoconstriction in isolated human anterior tibial artery. One of the reasons for higher potency of lacidipine could be a higher density of L-type than of T-type Ca2+ channels in tissue of the human anterior tibial artery.
- Subjects
LACIDIPINE; ARTERIES; CALCIUM antagonists; DRUGS; ANTIHYPERTENSIVE agents; CALCIUM channels
- Publication
Pflügers Archiv: European Journal of Physiology, 2000, Vol 440, pR147
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s004240000041