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- Title
Anti- Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species.
- Authors
Rocha, Tábitha; Brum Vieira, Patrícia; Gnoatto, Simone; Tasca, Tiana; Gosmann, Grace
- Abstract
Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide. The pathogen has been associated with serious health consequences including predisposition to cervical cancer and adverse pregnancy outcomes and infertility. It also acts as a co-factor in HIV transmission and acquisition. The 5-nitroimidazole drugs are used in the treatment, however, treatment noncompliance is observed, and a growing number of T. vaginalis isolates resistant to the drugs have been related. Saponins are natural products possessing many biological activities such as antiprotozoan activity. The aim of this study was to evaluate the anti- T. vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Saponins from Passiflora alata and Quillaja saponaria presented the best anti- T. vaginalis activity (MIC = 0.025%). In addition, all samples induced erythrocyte lysis and LDH release. As far as we know, this is the first report demonstrating the potential anti- T. vaginalis activity of these saponins.
- Subjects
TRICHOMONAS vaginalis; SAPONINS; QUILLAJA; PASSIFLORA; HOLLIES; ZOOFLAGELLATES; CERVICAL cancer; THERAPEUTICS
- Publication
Parasitology Research, 2012, Vol 110, Issue 6, p2551
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-011-2798-1