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- Title
Editorial: Sodium/hydrogen exchange and cardioprotection.
- Authors
Gross, Garrett J.
- Abstract
The article focuses on sodium/hydrogen exchanger (NHE), which is the major cardiac membrane transporter responsible for the control of intracellular pH in the myocyte under normal conditions. The NHE-1 is a plasma membrane protein that consists of an N-terminal hydrophobic domain that transports sodium and hydrogen and a C-terminal hydrophilic domain which regulates the N-terminal domain and is subject to phosphorylation by several protein kinases. Inhibiting NHE-1 attenuates the remodelling and hypertrophic process which contributes to heart failure.
- Subjects
HEART diseases; SODIUM; HYDROGEN; MUSCLE cells; CELL membranes; PHOSPHORYLATION
- Publication
Basic Research in Cardiology, 2001, Vol 96, Issue 4, p299
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950170035