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- Title
O-028 POSTOPERATIVE OLIGO-RECURRENCE OF NON-SMALL-CELL LUNG CANCER: CLINICAL FEATURES AND SURVIVAL.
- Authors
Hishida, Tomoyuki; Yoshida, J.; Aokage, K.; Nagai, K.
- Abstract
Objectives: Postoperative recurrences of non-small-cell lung cancer (NSCLC) are usually disseminated and incurable. Recently, the concept of oligo-recurrence (OR) which is theoretically treatable by local therapy has been proposed in several cancers. The aim of this study is to clarify clinical features and outcomes of OR patients with resected NSCLC.Methods: Among 3275 patients with resected pathologic Stage IA-IIIB NSCLC between 1993 and 2011, 768 patients developed recurrence and were included in this study. OR was defined as locoregional or distant recurrence limited to one organ and fewer than 3 lesions per involved organ. Other recurrences were classified as multiple recurrences (MRs). Second primary lung cancer and local recurrence arising in surgical margin were excluded.Results: OR and MR were identified in 162 (21%) and 606 (79%) patients. Hundred and twenty-nine patients (80%) of the OR group had solitary recurrence. OR locations were regional lymph nodes in 43 (27%), brain in 40 (25%), lung in 37 (23%), bone in 18 (11%), chest wall in 7, adrenal gland in 4, and others (skin/liver/kidney/stomach/intestine) in 13. Post-recurrence overall survival (PR-OS) was significantly better in OR than MR (5-year PR-OS: 31% vs 8%, P < 0.001), and OR location did not affect PR-OS (5-year PR-OS: locoregional 28%, distant 34%, P = 0.793). Treatment of OR included 84 patients (52%) with definitive local therapy (DLT) such as surgery, radiosurgery, and definitive radiotherapy, 21 (13%) DLT plus chemotherapy, 10 (6%) chemotherapy, and 48 (29%) supportive care. Five-year progression-free survival after treatment including DLT was 18%. OR locations in the 5-year progression-free survivors included lymph node, lung, brain, adrenal, and rib.Conclusions: This study indicated oligo-recurrence (OR) in resected NSCLC was a distinct subgroup with long-term survival irrespective of recurrence location. A subset of “true” OR which was considered to be cured by DLT was also observed.Disclosure: No significant relationships.
- Publication
Interactive Cardiovascular & Thoracic Surgery, 2014, Vol 18, Issue suppl_1, pS7
- ISSN
1569-9293
- Publication type
Article
- DOI
10.1093/icvts/ivu167.28