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- Title
Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
- Authors
Li, Weiwen; Sun, Debin; Lv, Zhuqing; Wei, Yueqiu; Zheng, Liyun; Zeng, Tingting; Zhao, Jialu
- Abstract
Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues. In addition, IGFBP-4 could inhibit lung cancer cell proliferation, migration and invasion, and suppress the phosphorylation of PI3 K/AKT, ERK, and CREB. These results indicate that IGFBP-4 has potent antitumor effects in non-small cell lung cancer cells.
- Subjects
SOMATOMEDIN; CYCLOOXYGENASE 2; CANCER cell proliferation; CELL migration; LUNG cancer
- Publication
Cell Biology International, 2017, Vol 41, Issue 4, p384
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.10732