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- Title
Real-world evidence of cytomegalovirus reactivation in non-Hodgkin lymphomas treated with bendamustine-containing regimens.
- Authors
Pezzullo, Luca; Giudice, Valentina; Serio, Bianca; Fontana, Raffaele; Guariglia, Roberto; Martorelli, Maria Carmen; Ferrara, Idalucia; Mettivier, Laura; Bruno, Alessandro; Bianco, Rosario; Vaccaro, Emilia; Pagliano, Pasquale; Montuori, Nunzia; Filippelli, Amelia; Selleri, Carmine
- Abstract
Cytomegalovirus (CMV) reactivation during chemotherapy or after organ or hematopoietic stem cell transplantation is a major cause of morbidity and mortality, and the risk of reactivation increases with patients’ age. Bendamustine, an alkylating agent currently used for treatment of indolent and aggressive non-Hodgkin lymphomas, can augment the risk of secondary infections including CMV reactivation. In this real-world study, we described an increased incidence of CMV reactivation in older adults (age >60 years old) with newly diagnosed and relapsed/refractory indolent and aggressive diseases treated with bendamustine-containing regimens. In particular, patients who received bendamustine plus rituximab and dexamethasone were at higher risk of CMV reactivation, especially when administered as first-line therapy and after the third course of bendamustine. In addition, patients with CMV reactivation showed a significant depression of circulating CD4+ T cell count and anti-CMV IgG levels during active infection, suggesting an impairment of immune system functions which are not able to properly face viral reactivation. Therefore, a close and early monitoring of clinical and laboratory findings might improve clinical management and outcome of non-Hodgkin lymphoma patients by preventing the development of CMV disease in a subgroup of subjects treated with bendamustine more susceptible to viral reactivation.
- Publication
Open Medicine, 2021, Vol 16, Issue 1, p672
- ISSN
2391-5463
- Publication type
Article
- DOI
10.1515/med-2021-0274