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- Title
呼吸机相关性肺炎患者血清 NAMPT、YKL-40、sTREM-1 水平 与病情程度及预后的关系研究.
- Authors
庄新梅; 张 霞; 黄 颖; 郭婉婷; 花 蕾
- Abstract
Objective: To study the relationship between niacinamide phosphoribontransferase(NAMPT), chitosan glycosinase3-like protein 1(YKL-40), soluble myeloid triggering receptor-1(sTREM-1) and disease severity and prognosis in patients with ventilator-associated pneumonia(VAP). Methods: A total of 120 patients with VAP who were admitted to our hospital from February2019 to February 2021 were selected as the research object. They were divided into 40 cases in the low-risk group, 45 cases in the medium-risk group and 35 cases in the high-risk group according to the disease severity. 50 healthy physical examination personnel in the same period were taken as the control group. The serum NAMPT, YKL-40 and sTREM-1 levels in each group were detected and compared. In addition, patients with VAP were divided into death group and survival group according to 28 day survival. The basic data,treatment situation and serum NAMPT, YKL-40 and sTREM-1 levels were compared between the two groups. The influencing factors of prognosis of patients with VAP were analyzed by multivariate Logistic regression. Results: The serum NAMPT, YKL-40 and sTREM-1levels in patients with VAP were higher than those in control group physical examination personnel, and the levels of these three serum indexes were increased with the disease severity(P<0.05). The serum NAMPT, YKL-40 and sTREM-1 levels in death group patients were higher than those in survival group patients(P<0.05). Univariate analysis showed that age, diabetes mellitus, body mass Index(BMI), mechanical ventilation time, prophylactic use of antibiotics and tracheotomy were all correlated with prognosis of patients with VAP(P<0.05). Multivariate Logistic regression analysis showed that age ≥65 years, long mechanical ventilation time, no prophylactic use of antibiotics, tracheotomy and abnormal elevation of serum NAMPT, YKL-40 and sTREM-1 levels were all adverse factors for prognosis of patients with VAP(all OR>1, P<0.05). Conclusion: Serum NAMPT, YKL-40 and sTREM-1 levels are closely correlated with the disease severity and prognosis of patients with VAP. The prognosis of patients with VAP is affected by age, mechanical ventilation time, antibiotic use, tracheotomy and serum levels of NAMPT, YKL-40 and STREM-1, etc.
- Subjects
LOGISTIC regression analysis; VENTILATOR-associated pneumonia; BODY mass index; ARTIFICIAL respiration; UNIVARIATE analysis
- Publication
Progress in Modern Biomedicine, 2023, Vol 23, Issue 4, p671
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2023.04.014