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- Title
Clinical Effect of GEMOX Combined with Intensity Modulated Radiation Therapy on Locally Advanced Pancreatic Cancer.
- Authors
ZHOU Jiu-peng; QIN Tian-jie; SUN Hong; YANG Hai-xia
- Abstract
Objective To investigate the therapeutic effect and toxic reactions of GEMOX combined with intensity modulated radiation therapy (IMRT) in treatment of locally advanced pancreatic cancer. Methods We retrospectively analyzed the clinical data of 46 patients with locally advanced pancreatic cancer who admitted in our hospital from January 2006 to July 2011. The patients were randomly divided into two groups: control group (single radiotherapy group) and combination radiotherapy group, with 23 patients in each group. Patients in the control group were given single IMRT, while patients in the combination radiotherapy group were given GEMOX combined with IMRT. Results All patients completed the planned treatment. For the control group and combination therapy group, the total effective rate was 43.4% and 78.2% , the incidence of one marrow depression was 4.3% and 100.0%, the pain alleviating rate was 69.6% and 82.6%, the one-year survival rate was 34.70% and 65.21%, the two-year survival rate was 21.73% and 39.13% , and the incidence of gastric reactions was 26.1% and 95.6% , respectively. There were statistically significant differences in the above indexes between two groups (P < 0.05) . The life quality of all patients in the two groups was imporved and there was no therapy related death. The adverse reactions of patients in two groups were all alleviated after symptomatic treatment. Conclusion GEMOX combined with IMRT has better effect than single radiotherapy on locally advanced pancreatic cancer in improving the local control rate, prolonging the survival time, alleviating pain and improving the life quality of patients, but has more tolerant toxic and adverse reactions.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p101
- ISSN
2095-610X
- Publication type
Article