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- Title
Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation.
- Authors
McEwan, Ashley; Greenwood, Matthew; Ward, Christopher; Ritchie, David; Szer, Jeff; Gardiner, Elizabeth; Colic, Andriana; Sipavicius, Julija; Panek‐Hudson, Yvonne; Kerridge, Ian
- Abstract
Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient‐ and transplant‐specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant‐associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
- Subjects
ENDOTHELIUM; CAPILLARY leak syndrome; ADRENOCORTICAL hormones; HEMATOPOIETIC stem cell transplantation; HEPATIC veno-occlusive disease; POSTERIOR leukoencephalopathy syndrome; DISEASE management
- Publication
Internal Medicine Journal, 2023, Vol 53, Issue 12, p2162
- ISSN
1444-0903
- Publication type
Article
- DOI
10.1111/imj.16188