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- Title
Deep brain stimulation of subthalamic nucleus increases dopamine transporter binding in the ventral striatum in patients with Parkinson's disease.
- Authors
Takao Nozaki; Kenji Sugiyaka; Tetsuya Asakawa; Hiroki Namba; Masamichi Yokokura; Tatsuhiro Terada; Yasuomi Ouchi
- Abstract
Introduction: It is well known that deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates motor symptoms of Parkinson's disease (PD). However, the effects of STN-DBS on presynaptic dopaminergic systems are still unclear. The nigrostriatal neuronal degeneration usually continues to progress in PD patients without DBS. Positron emission tomography (PET) with 11C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane ([11C]CFT) is a marker for loss of presynaptic dopamine transporters in the striatum in PD. Here we used [11C]CFT PET in order to evaluate binding to the dopamine transporter in PD patients before and after neurosurgical treatment with STN-DBS. Methods: 10 patients with PD were examined with [11C]CFT-PET pre-operatively (within one month before surgery), and 12 months after surgery. [11C]CFT binding was evaluated using the region-of interest (ROI) method. ROIs were set bilaterally over the head of the caudate (divided into ventral and dorsal segments at its midpoint), nucleus accumbens, and putamen (divided into anterior-ventral, anterior-dorsal, posterior-ventral, and posterior-dorsal segments at its midpoint). Results: There was a significant reduction in postoperative [11C]CFT uptake in the posterior-dorsal putamen contralateral to the clinically more affected side (to 7.4% of the preoperative mean, p<0.05). However, there was significant increase in [11C]CFT uptake in the contralateral anterior-ventral putamen and ipsilateral ventral caudate (to 4.9% and 10.1% of the preoperative mean, respectively, p<0.05). [11C]CFT uptake was also increased in the bilateral nucleus accumbens although it did not reach statistical significance. Conclusion: Our result showed that STN-DBS increases dopamine transporters in the ventral striatum, which is different from natural course of PD. This result may indicate the compensative and neuroprotective effect of STN-DBS on the presynaptic dopaminergic systems of PD.
- Publication
Stereotactic & Functional Neurosurgery, 2017, Vol 95, p43
- ISSN
1011-6125
- Publication type
Article