Found: 26
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YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.
- Published in:
- EMBO Reports, 2015, v. 16, n. 1, p. 97, doi. 10.15252/embr.201438976
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- Publication type:
- Article
The unfolded protein response regulator ATF6 promotes mesodermal differentiation.
- Published in:
- Science Signaling, 2018, v. 11, n. 517, p. 1, doi. 10.1126/scisignal.aan5785
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- Publication type:
- Article
Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 9, p. 1721, doi. 10.1042/BCJ20190312
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- Publication type:
- Article
Modulating protein quality control.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.18431
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- Publication type:
- Article
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.15550
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- Publication type:
- Article
ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 10, p. 1661, doi. 10.3390/cells11101661
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- Publication type:
- Article
Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action ( This work was supported by the NIH (DK 46335), the Skaggs Institute for Chemical Biology, and the Lita Annenberg Hazen Foundation. H.R. thanks the Skaggs Institute for Chemical Biology for a postdoctoral fellowship. Additional support was provided by the Robert A. Welch Foundation (J.C.S). Use of the Argonne National Laboratory Structural Biology Center beam lines at the Advanced Photon Source was supported by the United States Department of Energy, Office of Energy Research, under contract W-31-109-ENG-38. Use of the BioCARS Sector 14 was supported by the National Institutes of Health National Center for Research Resources. We thank the General Clinical Research Center of The Scripps Research Institute (supported by NIH grant RR00833) for providing blood plasma through the normal donor blood drawing program. )
- Published in:
- Angewandte Chemie, 2003, v. 115, n. 24, p. 2864, doi. 10.1002/ange.200351179
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- Publication type:
- Article
PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37207-0
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- Publication type:
- Article
Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out.
- Published in:
- IUBMB Life, 2015, v. 67, n. 6, p. 404, doi. 10.1002/iub.1386
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- Publication type:
- Article
Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28271-2
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- Publication type:
- Article
Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23495-0
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- Publication type:
- Article
P3‐146: FORMATION AND TOXICITY OF TRANSTHYRETIN (TTR) OLIGOMERS IN VITRO AND IN PATIENTS WITH FAMILIAL AMYLOID POLYNEUROPATHY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1123, doi. 10.1016/j.jalz.2018.06.1503
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- Publication type:
- Article
Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3.
- Published in:
- Antioxidants, 2020, v. 9, n. 10, p. 1025, doi. 10.3390/antiox9101025
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- Publication type:
- Article
Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3.
- Published in:
- Antioxidants, 2020, v. 9, n. 10, p. 1025, doi. 10.3390/antiox9101025
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- Publication type:
- Article
Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39775-w
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- Publication type:
- Article
Chaperones in Neurodegeneration.
- Published in:
- Journal of Neuroscience, 2015, v. 35, n. 41, p. 13853, doi. 10.1523/JNEUROSCI.2600-15.2015
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- Publication type:
- Article
Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA<sub>A</sub> receptors.
- Published in:
- Cell & Bioscience, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13578-022-00783-w
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- Publication type:
- Article
The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021.
- Published in:
- FASEB Journal, 2021, v. 35, n. 6, p. 1, doi. 10.1096/fj.202100566
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- Publication type:
- Article
Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5743, doi. 10.3390/ijms21165743
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- Publication type:
- Article
Targeting protein aggregation for the treatment of degenerative diseases.
- Published in:
- 2015
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- Publication type:
- journal article
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08129-2
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- Publication type:
- Article
Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action ( This work was supported by the NIH (DK 46335), the Skaggs Institute for Chemical Biology, and the Lita Annenberg Hazen Foundation. H.R. thanks the Skaggs Institute for Chemical Biology for a postdoctoral fellowship. Additional support was provided by the Robert A. Welch Foundation (J.C.S). Use of the Argonne National Laboratory Structural Biology Center beam lines at the Advanced Photon Source was supported by the United States Department of Energy, Office of Energy Research, under contract W-31-109-ENG-38. Use of the BioCARS Sector 14 was supported by the National Institutes of Health National Center for Research Resources. We thank the General Clinical Research Center of The Scripps Research Institute (supported by NIH grant RR00833) for providing blood plasma through the normal donor blood drawing program. )
- Published in:
- Angewandte Chemie International Edition, 2003, v. 42, n. 24, p. 2758, doi. 10.1002/anie.200351179
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- Publication type:
- Article
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid.
- Published in:
- EMBO Journal, 2023, v. 42, n. 15, p. 1, doi. 10.15252/embj.2023113908
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- Publication type:
- Article
Lining up for quality control: linear ubiquitin and proteotoxicity.
- Published in:
- EMBO Journal, 2019, v. 38, n. 9, p. N.PAG, doi. 10.15252/embj.2019101985
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- Publication type:
- Article
The endoplasmic reticulum HSP40 co-chaperone ERdj3/ DNAJB11 assembles and functions as a tetramer.
- Published in:
- EMBO Journal, 2017, v. 36, n. 15, p. 2296, doi. 10.15252/embj.201695616
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- Publication type:
- Article
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.
- Published in:
- EMBO Journal, 2015, v. 34, n. 1, p. 4, doi. 10.15252/embj.201488896
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- Publication type:
- Article