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- Title
Ubiquitin specific protease 21 upregulation in breast cancer promotes cell tumorigenic capability and is associated with the NOD-like receptor signaling pathway.
- Authors
LIANG PENG; YI HU; DEMENG CHEN; RUIXIA LINGHU; YINGZHE WANG; XIAOXUE KOU; JUNLAN YANG; SHUNCHANG JIAO
- Abstract
Ubiquitination and deubiquitination have emerged as critical regulators in cancer. In the present study, the expression pattern of 50 ubiquitin-specific proteases (USPs) was summarized in breast cancer using a bioinformatics approach, and USP21 was identified as the most altered gene in breast cancer. In particular, expression of USP21 in triple negative breast cancer (TNBC) cell lines was greater compared with other subtypes of breast cancer. Knockdown of USP21 in TNBC cells inhibited cell proliferation, migration and invasion. Microarray profiling of the USP21 knockdown cells revealed significant downregulation of multiple genes associated with the NOD-like receptor signaling pathway. The results of the present study suggest that USP21 has a significant role in TNBC progression, and therefore may represent a novel therapeutic target.
- Subjects
UBIQUITINATION; BREAST cancer treatment; CELLULAR signal transduction; MICROARRAY technology; PROTEIN expression
- Publication
Oncology Letters, 2016, Vol 12, Issue 6, p4531
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.5263