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- Title
Serum expression levels of microRNA-382-3p, -598-3p, -1246 and -184 in breast cancer patients.
- Authors
LUN FU; ZHAOYUN LI; JIE ZHU; PAN WANG; GUANGMIN FAN; YUECHU DAI; ZHIBAO ZHENG; YANG LIU
- Abstract
The purpose of the present study was to investigate the serum levels of microRNA (miRNA/miR)-382-3p, -598-3p, -1246 and -184 in breast cancer patients and to assess their feasibility as biomarkers for breast cancer screening. Serum samples were obtained from 100 breast cancer patients and 40 age-matched healthy control subjects in Taizhou Central Hospital (Taizhou, Zhejiang, China) between January 2013 and September 2014. The serum expression levels of miR-382-3p, -598-3p, -1246 and -184 were determined by stem-loop reverse transcription-quantitative polymerase chain reaction. Receiver operating characteristic curves were drawn to evaluate the sensitivity and specificity of the serum miRNA expression levels for the screening of breast cancer. miR-382-3p and -1246 were significantly upregulated in the serum of the breast cancer patients, while miR-598-3p and -184 were significantly downregulated. The sensitivity and specificity to detect breast cancer were as follows: miR-382-3p, 52.0 and 92.5%; miR-598-3p, 95.0 and 85.0%; miR-1246, 93.0 and 75.0%; and miR-184, 87.5 and 71.0%, respectively. The expression levels of the four serum miRNAs were not correlated with the patients' clinical stage. In summary, miR-382-3p, -598-3p, -1246 and -184 are all involved in the development of breast cancer, and are promising biomarkers for breast cancer detection.
- Subjects
SERUM; MICRORNA; BREAST cancer patients; GENE expression; POLYMERASE chain reaction
- Publication
Oncology Letters, 2016, Vol 12, Issue 1, p269
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4582