We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinct kinetics of immunoglobulin isotypes reveal early diagnosis and disease severity of COVID‐19: A 6‐month follow‐up.
- Authors
Yu, Siyang; An, Jianghong; Liao, Xuejiao; Wang, Haiyan; Ma, Fen; Li, Dapeng; Li, Aimin; Liu, Weilong; Zhang, Siwei; Liao, Mingfeng; Liu, Lei; Zhao, Juanjuan; Xing, Shaojun; Wei, Lanlan; Zhang, Zheng
- Abstract
There were more robust IgA, IgG, and IgM responses in severe patients, more rapid but less robust IgA and IgG responses in asymptomatic and mild patients. To investigate whether the serological assay of different antibody isotypes could improve the early diagnostic power of COVID-19 patients, the seroconversion rates of single or combined antibody isotypes and the detection of viral RNA in the first month after disease onset were analyzed irrespective of disease severity. This study provides a comprehensive dynamic analysis of different antibody isotypes against SARS-CoV-2 and their relation to disease severity or early COVID-19 diagnosis in a large patient cohort over a 6-month follow-up period, which will benefit the early diagnosis and assessment of disease severity for COVID-19. To understand the correlation between antibody responses and disease severity, the levels of viral-specific IgA, IgG, and IgM were analyzed in four groups, and their kinetics are shown in Figures 1A-C and 2A-C. All three antibody isotypes (IgA, IgG, and IgM) peaked 1 month after disease onset (Figure 1A-C).
- Subjects
COVID-19; DIAGNOSIS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN G; EARLY diagnosis; VIRAL antibodies; SARS-CoV-2
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 3, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.342