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- Title
Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort.
- Authors
van Mierlo, Minke M. F.; Caspers, Peter J.; Jansen, Marieke S.; Puppels, Gerwin J.; Nouwen, Anouk E. M.; Bronner, Madelon B.; Pardo, Luba M.; van Geel, Michel; Pasmans, Suzanne G. M. A.
- Abstract
Furthermore, the NMF content in patients with a single mutation in I FLG i was significantly different compared to both wild-type patients and patients with 2 mutations in I FLG i ( I p i < .01, Figure S2). The aim of our study was to screen the entire encoding region of I FLG i for potential mutations and to validate whether NMF could be used as a biomarker for I FLG i genotype in an unselected multi-ethnic clinical cohort of children with mild-to-severe disease. Raman spectroscopy is a rapid and non-invasive technique to measure natural moisturizing factor content in AD Natural moisturizing factor can predict I FLG i genotype with a sensitivity of 97% and specificity of 87% The thenar eminence's nonlesional skin is a suitable location to predict I FLG i genotype To the Editor, Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades.
- Subjects
ATOPIC dermatitis; FILAGGRIN; BIOMARKERS; PEDIATRICS; CHILD patients; PEDIATRIC dermatology
- Publication
Clinical & Experimental Allergy, 2021, Vol 51, Issue 11, p1510
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.14001