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- Title
Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease.
- Authors
Muscheites, Jutta; Wigger, Marianne; Drueckler, Erdmute; Fischer, Dagmar-Christiane; Kundt, Guenther; Haffner, Dieter
- Abstract
The efficacy and acceptability of cinacalcet for treatment of secondary hyperparathyroidism (SHPT) was assessed in seven pediatric patients suffering from end-stage renal disease (ESRD) presenting with inadequately controlled SHPT despite conventional management. Patients received daily treatment with cinacalcet (dosage 0.25 mg/kg body weight) for a total of 4 weeks. Within 4 h after application of the first dose, median levels of serum parathyroid hormone (PTH) had decreased from 932 pg/ml (range 511–1,938 pg/ml) to 584 pg/ml (88–937 pg/ml), and final pre-dose values after 4 weeks were 199 pg/ml (121–940 pg/ml; each P < 0.05 versus baseline). Median concentrations of serum calcium (Ca) decreased within 4 h of the first administration, from 2.56 mmol/l to 2.38 mmol/l, returning to 2.58 mmol/l at 24 h, and they remained slightly decreased compared to baseline values thereafter (each P < 0.05 versus baseline). Both the median levels of serum phosphorus (P) and the Ca × P ion product decreased significantly during the 4-week period. Cinacalcet was well tolerated and without drug-related adverse effects. Thus, even with approximately half of the dose usually given to adult dialysis patients, PTH and the Ca × P ion product were markedly reduced in pediatric ESRD patients presenting with inadequately controlled SHPT. Therefore, our results support the initiation of a randomized, controlled, long-term trial in children.
- Subjects
CHRONIC kidney failure; HYPERPARATHYROIDISM; HYPERCALCEMIA; CALCIFICATION; HYPOCALCEMIA; KIDNEY disease treatments; JUVENILE diseases
- Publication
Pediatric Nephrology, 2008, Vol 23, Issue 10, p1823
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-008-0810-5