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- Title
Metaraminol (Aramine®) in the management of a significant amlodipine overdose.
- Authors
Wood, D. M.; Wright, K. D.; Jones, A. L.; Dargan, P. I.
- Abstract
Objective: To report a patient with a significant amlodipine self-poisoning who failed to clinically respond to conventional treatment and was managed with metaraminol (Aramine®). Patient: A 43-year old male presenting after ingestion of 560 mg amlodipine, who failed to respond clinically to treatment with fluid resuscitation, calcium salts, glucagon and norepinephrine/epinephrine inotropic support. Main results: Following a loading bolus of 2 mg and intravenous infusion (83 μg/min) of metaraminol (Aramine®) there was improvement in his blood pressure, cardiac output and urine output. Conclusions: This is the first case report of the beneficial use of metaraminol (aramine) in the management of significant amlodipine poisoning unresponsive to conventional therapy.
- Subjects
AMLODIPINE; CALCIUM antagonists; CRITICAL care medicine; PANCREATIC secretions; INTRAVENOUS therapy; HEMODYNAMICS
- Publication
Human & Experimental Toxicology, 2005, Vol 24, Issue 7, p377
- ISSN
0960-3271
- Publication type
Article
- DOI
10.1191/0960327105ht538oa