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- Title
A proposed model of xeno-keratoplasty using 3D printing and decellularization.
- Authors
Xinyu Wang; Elbahrawi, Rawdah Taha; Abdukadir, Azhar Mohamud; Ali, Zehara Mohammed; Chan, Vincent; Corridon, Peter R.
- Abstract
Corneal opacity is a leading cause of vision impairment and suffering worldwide. Transplantation can effectively restore vision and reduce chronic discomfort. However, there is a considerable shortage of viable corneal graft tissues. Tissue engineering may address this issue by advancing xeno-keratoplasty as a viable alternative to conventional keratoplasty. In particular, livestock decellularization strategies offer the potential to generate bioartificial ocular prosthetics in sufficient supply to match existing and projected needs. To this end, we have examined the best practices and characterizations that have supported the current state-of-the-art driving preclinical and clinical applications. Identifying the challenges that delimit activities to supplement the donor corneal pool derived from acellular scaffolds allowed us to hypothesize a model for keratoprosthesis applications derived from livestock combining 3D printing and decellularization.
- Subjects
VISION disorders; BIOPRINTING; CORNEAL opacity; TISSUE engineering; CORNEA; TISSUE scaffolds; THREE-dimensional printing
- Publication
Frontiers in Pharmacology, 2023, p01
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2023.1193606