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- Title
Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study.
- Authors
Nielsen, Katrine Finderup; Nielsen, Lise Birk; Lomholt, Frederikke Kristensen; Nørgaard, Sarah Kristine; Slotved, Hans-Christian; Dalby, Tine; Fuursted, Kurt; Jørgensen, Charlotte Sværke; Valentiner-Branth, Palle
- Abstract
This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference.
- Subjects
PNEUMOCOCCAL vaccines; VACCINE effectiveness; COHORT analysis; CONFIDENCE intervals; VACCINATION; FOOT &; mouth disease
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2022, Vol 41, Issue 12, p1473
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-022-04513-5