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- Title
Hematological Risk Factors for High-Altitude Headache in Chinese Men Following Acute Exposure at 3,700 m.
- Authors
He Huang; Bao Liu; Gang Wu; Gang Xu; Bing-Da Sun; Yu-Qi Gao
- Abstract
Background: High-altitude headache (HAH) is a notably common disorder affecting the daily life of travelers ascending to high altitude. Hematological parameters are important clinical examinations for various diseases. Today, hematological characteristics of HAH remain unrevealed. Above all, we aimed to ascertain hematological characteristics and independent risk factors/predictors associated with HAH before and after exposure at 3,700m. Methods: Forty five healthy men were enrolled in present study. Demographic and clinical data, physiological and hematological parameters were collected 3 days before the ascent and after acute exposure at 3,700m. Results: HAH patients featured significantly lower white blood cell count (WBC), neutrophil count (NEU#) and percentage (NEU%), and higher percentage of lymphocyte (LYM%) at 3,700m and significantly lower NEU#, reticulocyte count (RET#) and percentage (RET%) at sea level (all P < 0.05). HAH severity was significantly and negatively associated with WBC, NEU#, and NEU% at 3,700m and RET# at sea level, whereas was positively associated with LYM% at 3,700m (all P < 0.05). Moreover, we have found that RET# at sea level and NEU% at 3,700m was an independent predictor and risk factor for HAH, respectively. Conclusion: The present study is the first to examine the hematological characteristics of HAH. Furthermore, lower RET# at sea level and lower NEU% at 3,700m is a novel independent predictor and risk factor for HAH, respectively.
- Subjects
MOUNTAIN sickness; HIGH altitude cerebral edema; HEMATOLOGY; LYMPHOCYTES; DISEASE risk factors
- Publication
Frontiers in Physiology, 2017, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2017.00801