We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association Mapping With Single-Feature Polymorphisms.
- Authors
Sung Kim; Keyan Zhao; Rong Jiang; Molitor, John; Borevitz, Justin O.; Nordborg, Magnus; Marjoram, Paul
- Abstract
We develop methods for exploiting ‘single-feature polymorphism’ data, generated by hybridizing genomic DNA to oligonucleotide expression arrays. Our methods enable the use of such data, which can be regarded as very high density, but imperfect, polymorphism data, for genomewide association or linkage disequilibrium mapping. We use a simulation-based power study to conclude that our methods should have good power for organisms like Arabidopsis thaliana, in which linkage disequilibrium is extensive, the reason being that the noisiness of single-feature polymorphism data is more than compensated for by their great number. Finally, we show how power depends on the accuracy with which single-feature polymorphisms are called.
- Subjects
GENETIC polymorphisms; GENOMICS; DNA; ARABIDOPSIS thaliana; OLIGONUCLEOTIDES; NUCLEOTIDES; GENETICS
- Publication
Genetics, 2006, Vol 173, Issue 2, p1125
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.105.052720