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- Title
Regional Variation on Rates of Bronchopulmonary Dysplasia and Associated Risk Factors.
- Authors
Rojas, María Ximena; Rojas, Mario Augusto; Lozano, Juan Manuel; Rondón, Martín Alonso; Charry, Laura Patricia
- Abstract
Background. An abnormally high incidence (44%) of bronchopulmonary dysplasia with variations in rates among cities was observed in Colombia among premature infants. Objective. To identify risk factors that could explain the observed high incidence and regional variations of bronchopulmonary dysplasia. Study Design. A case-control study was designed for testing the hypothesis that differences in the disease rates were not explained by differences in city-of-birth specific population characteristics or by differences in respiratory management practices in the first 7 days of life, among cities. Results. Multivariate analysis showed that premature rupture of membranes, exposure to mechanical ventilation after received nasal CPAP, no surfactant exposure, use of rescue surfactant (instead of early surfactant), PDA, sepsis and the median daily FIO2, were associated with a higher risk of dysplasia. Significant differences between cases and controls were found among cities. Models exploring for associations between city of birth and dysplasia showed that being born in the highest altitude city (Bogot'a) was associated with a higher risk of dysplasia (OR 1.82 95% CI 1.31-2.53). Conclusions. Bronchopulmonary dysplasia was manly explained by traditional risk factors. Findings suggest that altitudemay play an important role in the development of this disease. Prenatal steroids did not appear to be protective at high altitude.
- Subjects
COLOMBIA; PREGNANCY complications; ARTIFICIAL respiration; BRONCHOPULMONARY dysplasia; CHI-squared test; CONFIDENCE intervals; EPIDEMIOLOGY; PREMATURE infants; MULTIVARIATE analysis; NEONATAL intensive care; PULMONARY surfactant; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; NEONATAL intensive care units; DISEASE incidence; CASE-control method; CONTINUOUS positive airway pressure; DATA analysis software; DISEASE risk factors
- Publication
ISRN Pediatrics, 2012, p1
- ISSN
2090-469X
- Publication type
Article
- DOI
10.5402/2012/685151