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- Title
Endometrial and Ovarian Cancer with MR Imaging Importance of Serum HE4 and CA 125 Levels in the Extent of Disease at Evaluation.
- Authors
Topdağı Yılmaz, Emsal Pınar; Kumtepe, Yakup
- Abstract
Objective: Currently, no clinically useful tumor marker is available for primary diagnosis in endome-trial cancer. Human epididymis protein-4 (HE-4) has high sensitivity and specificity as a tumor marker. Further, HE-4 has been shown to be elevated in early stage endometrial cancer and is more sensitive than CA 1 25. In our study, CA 1 25 and HE-4 reputation as a tumor marker for diagnosis of ovarian and endometrial cancer with the use of both the availability and affect the way we investigated the rate of diagnosis. Materials and Methods: Here 20 patients with ovarian cancer, 26 patients with endometrial cancer, which had been histologically diagnosed, and 40 healthy volunteers were included. Peripheral blood samples were taken and serum CA 1 25 and HE-4 were tested. Results: Serum CA 1 25 and HE-4 levels in patients with ovarian cancer were found to be significantly higher than those in healthy volunteers (p<0.05). Receiver-operating characteristic (ROC) analysis was performed. For patients with ovarian cancer and healthy controls, the CA 1 25 (0.83) and HE-4 (0.84) levels showed increased sensitivity (95%). There was no significant difference in the CA 1 25 levels in patients with endometrial cancer and healthy controls (p>0.05), whereas HE-4 levels were found to be higher in patients with endometrial cancer than in healthy controls (p<0.05). ROC analysis was performed. For endometrial cancer patients and healthy controls, the CA 1 25 (0.59) and HE-4 (0.63) levels showed increased sensitivity (88.5%). Conclusion: In ovarian and endometrial cancer, wherein early diagnosis is the most important factor for prognosis and survival, HE-4 is a new serum tumor marker that can be used with the aim of noninvasive diagnoses. For early diagnosis, the concomitant use of CA 1 25 and HE-4 is more effective and reliable than using either of them alone.
- Subjects
OVARIAN tumors; PROTEIN analysis; ENDOMETRIAL tumors; HISTOLOGY; MAGNETIC resonance imaging; TUMOR antigens; TUMOR markers; CONTROL groups; RECEIVER operating characteristic curves; EARLY diagnosis; DESCRIPTIVE statistics; EVALUATION; DIAGNOSIS
- Publication
Eurasian Journal of Medicine, 2016, Vol 48, Issue 3, p192
- ISSN
1308-8734
- Publication type
Article
- DOI
10.5152/eurasianjmed.2016.0259