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- Title
Association between omega-3 polyunsaturated fatty acids and osteoarthritis: results from the NHANES 2003–2016 and Mendelian randomization study.
- Authors
Liu, Yuxuan; Song, Feichao; Liu, Muchun; Huang, Xi; Xue, Shuyan; Zhang, Xuanyu; Hao, Huiqin; Zhang, Junfeng
- Abstract
Background: Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) exhibit potential as therapeutics for a variety of diseases. This observational and Mendelian randomization (MR) study aims to explore the relationship between omega-3 PUFAs and osteoarthritis (OA). Methods: Excluding individuals under 20 years old and those with missing data on relevant variables in the National Health and Nutrition Examination Survey (NHANES) spanning from 2003 to 2016, a total of 22 834 participants were included in this cross-sectional study. Weighted multivariable-adjusted logistic regression was used to estimate the association between omega-3 PUFAs and OA in adults. Moreover, restricted cubic splines were utilized to examine the dose-response relationship between omega-3 PUFAs and OA. To further investigate the potential causal relationship between omega-3 PUFAs and OA risk, a two-sample MR study was conducted. Furthermore, the robustness of the findings was assessed using various methods. Results: Omega-3 PUFAs intake were inversely associated with OA in adults aged 40 ∼ 59 after multivariable adjustment , with a nonlinear relationship observed between omega-3 PUFAs intake and OA . The IVW results showed there was no evidence to suggest a causal relationship between omega-3 PUFAs and OA risk . Conclusions: Omega-3 PUFAs were inversely associated with OA in adults aged 40 ∼ 59. However, MR studies did not confirm a causal relationship between the two.
- Subjects
UNSATURATED fatty acids; OMEGA-3 fatty acids; RANDOMIZATION (Statistics); MULTIVARIABLE testing; OMEGA-6 fatty acids; HEALTH &; Nutrition Examination Survey; OSTEOARTHRITIS
- Publication
Lipids in Health & Disease, 2024, Vol 23, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-024-02139-4