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- Title
Role of nitric oxide in hepatic ischemia-reperfusion injury.
- Authors
Siriussawakul, Arunotai; Zaky, Ahmed; Lang, John D.
- Abstract
Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO.
- Subjects
NITRIC oxide; REPERFUSION injury; BLOOD flow; OXIDATIVE stress; CYTOKINES; LEUCOCYTES; CELL adhesion
- Publication
Annals of Gastroenterology & Hepatology, 2011, Vol 9, Issue 93, p6079
- ISSN
2043-023X
- Publication type
Article
- DOI
10.3748/wjg.v16.i48.6079