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- Title
Real-world effectiveness of cladribine as an escalation strategy for MS: Insights from the Czech nationwide ReMuS registry.
- Authors
Potuznik, Pavel; Drahota, Jiri; Horakova, Dana; Peterka, Marek; Mazouchova, Aneta; Matyas, David; Pavelek, Zbysek; Vachova, Marta; Recmanova, Eva; Stetkarova, Ivana; Libertinova, Jana; Mares, Jan; Stourac, Pavel; Grunermelova, Marketa; Martinkova, Alena; Adamkova, Jana; Hradilek, Pavel; Ampapa, Radek; Dufek, Michal; Kubala Havrdova, Eva
- Abstract
Background: Cladribine, a selective immune reconstitution therapy, is approved for the treatment of adult patients with highly active multiple sclerosis (MS). Objectives: Provide experience with cladribine therapy in a real-world setting. Methods: This is a registry-based retrospective observational cohort study. First, using data from the Czech nationwide registry ReMuS, we analysed patients who initiated cladribine from September 1, 2018 to December 31, 2021. Second, we analysed a subgroup of patients who initiated cladribine between September 1, 2018 to June 30, 2020, thus possessing a follow-up period of at least 2 years. We evaluated demographic and MS characteristics including disease-modifying therapies (DMTs) before and after cladribine administration, relapses, Expanded Disability Status Scale (EDSS), and adherence. Results: In total, 617 patients (335 with follow-up of at least 2 years) started cladribine therapy in the study period (mean age 37.0, mean disease duration 8.4 years, 74.1% females). In most cases, cladribine was administered as a second-line drug, a total of 80.7% had been escalated from a platform DMT. During 2 years before cladribine initiation, the average annualised relapse rate (ARR) was.67. Following cladribine initiation, the ARR decreased to.28 in the first year and.22 in the second year. Overall, across the entire two-year treatment period, 69.0% of patients were relapse-free and the average ARR was.25. As for EDSS development, the median baseline EDSS was 2.5 and remained stable even after 24 months. The adherence to treatment ranged of around 90%. Conclusion: This nationwide study confirms the efficacy of cladribine in real-world settings, especially in patients who are not treatment-naïve. In addition, the study shows an exceptionally high adherence rate, a finding that underscores the invaluable role of cladribine, but also the value of registry-based studies in capturing real-world clinical practice.
- Subjects
CZECH Republic; PATIENT compliance; MULTIPLE sclerosis; RESEARCH funding; ADENOSINES; SCIENTIFIC observation; RETROSPECTIVE studies; SYMPTOMS; DESCRIPTIVE statistics; LONGITUDINAL method; DRUG efficacy; DRUGS; EVALUATION
- Publication
Journal of Central Nervous System Disease, 2024, p1
- ISSN
1179-5735
- Publication type
Article
- DOI
10.1177/11795735241262743