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- Title
Amniotic membrane transplantation with or without autologous cultivated limbal stem cell transplantation for the management of partial limbal stem cell deficiency.
- Authors
Sharma, Namrata; Mohanty, Sujata; Jhanji, Vishal; Vajpayee, Rasik B
- Abstract
Purpose: To compare the outcomes of amniotic membrane transplantation (AMT) vs cultivated limbal stem cell transplantation (LSCT) in eyes with partial limbal stem cell deficiency (LSCD) following chemical burns.Methods: Eyes with unilateral partial LSCD (≤180° involvement) were randomized in two groups to undergo either pannus resection combined with AMT or pannus resection combined with LSCT in a tertiary eye care hospital. Primary outcome measures were time to corneal epithelialization and absence of conjunctivalization of the cornea. Patients were followed up at 1 week, 1, 3, 6, and 12 months after the surgical procedure.Results: There was no difference between mean age (30.85±5.8 vs 28.64±6.4 years, P=0.40) and sex distribution of patients between the two groups at baseline. Mean time to corneal epithelialization was 10.45±5.8 days in the AMT group and 11±3.9 days in the LSCT group (P=0.43). At the end of 1 year, there was no significant difference between the degree of conjunctivalization of cornea, (P=0.06) corneal vascularization, (P=0.08), and clarity (P=0.07) in both groups.Conclusion: Our study showed that AMT alone is a useful therapeutic modality in cases with partial LSCD due to ocular chemical injury. Stem cell transplantation may not be required in these cases.
- Subjects
AMNION; STEM cell transplantation; VISUAL acuity; CONJUNCTIVA; SCARS; LIMBAL stem cell deficiency
- Publication
Clinical Ophthalmology, 2018, Vol 12, p2103
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S181035