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- Title
Known Unknowns of Mammalian Mitochondrial DNA Maintenance.
- Authors
Pohjoismäki, Jaakko L. O.; Forslund, Josefin M. E.; Goffart, Steffi; Torregrosa‐Muñumer, Rubén; Wanrooij, Sjoerd
- Abstract
Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research.
- Subjects
MITOCHONDRIAL DNA; DNA replication; DNA repair; RIBONUCLEOTIDES; RNA
- Publication
BioEssays, 2018, Vol 40, Issue 9, p1
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.201800102