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- Title
The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!
- Authors
Gosavi, Prajakta; Gleeson, Paul A.
- Abstract
The Golgi apparatus in vertebrate cells consists of individual Golgi stacks fused together in a continuous ribbon structure. The ribbon structure per se is not required to mediate the classical functions of this organelle and the relevance of the 'ribbon' structure has been a mystery since first identified ultrastructurally in the 1950s. Recent advances recognize a role for the Golgi apparatus in a range of cellular processes, some mediated by signaling networks which are regulated at the Golgi. Here we review the cellular processes and signaling events regulated by the Golgi apparatus and, in particular, explore an emerging theme that the ribbon structure of the Golgi contributes directly to the regulation of these higher order functions.
- Subjects
VERTEBRATE anatomy; GOLGI apparatus; GLYCOSYLATION; CELL membranes; CELL fractionation; PHYSIOLOGY
- Publication
BioEssays, 2017, Vol 39, Issue 11, pn/a
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.201700063