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- Title
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer.
- Authors
Furuta, Takahisa; Ohashi, Kyoichi; Furuta, T; Ohashi, K; Kamata, T; Takashima, M; Kosuge, K; Kawasaki, T; Hanai, H; Kubota, T; Ishizaki, T; Kaneko, E
- Abstract
<bold>Background: </bold>Omeprazole is metabolized by S-mephenytoin 4'-hydroxylase (CYP2C19) in the liver. In persons with a poor-metabolizer genotype for CYP2C19, the therapeutic efficacy of omeprazole may be increased.<bold>Objective: </bold>To investigate whether CYP2C19 genotype status is associated with cure rates for Helicobacterpylori infection and peptic ulcer achieved by using dual therapy with omeprazole and amoxicillin.<bold>Design: </bold>Prospective cohort study.<bold>Setting: </bold>University hospital and health service center in Hamamatsu, Japan.<bold>Patients: </bold>62 patients with peptic ulcer and H. pylori infection.<bold>Intervention: </bold>Omeprazole and amoxicillin.<bold>Measurements: </bold>CYP2C19 genotype status and cure rates for H. pylori infection and peptic ulcer.<bold>Results: </bold>Cure rates for H. pylori infection were 28.6% (95% CI, 13.1% to 48.7%), 60% (CI, 38.6% to 83.0%), and 100% (CI, 66.4% to 100%) in the rapid-, intermediate-, and poor-metabolizer groups, respectively. Healing rates for both duodenal and gastric ulcer in the three groups were roughly parallel with cure rates for H. pylori infection.<bold>Conclusion: </bold>The results of the genotyping test for CYP2C19 seem to predict cure of H. pylori infection and peptic ulcer in patients who receive dual therapy with omeprazole and amoxicillin.
- Subjects
HELICOBACTER pylori infections; ULCER treatment; PEPTIC ulcer; OMEPRAZOLE; AMOXICILLIN; PENICILLIN; COMBINATION drug therapy; COMPARATIVE studies; GASTROINTESTINAL agents; HELICOBACTER diseases; HELICOBACTER pylori; HEME; LIVER; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; OXIDOREDUCTASES; RESEARCH; PHENOTYPES; EVALUATION research; GENOTYPES; THERAPEUTICS
- Publication
Annals of Internal Medicine, 1998, Vol 129, Issue 12, p1027
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-129-12-199812150-00006