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- Title
The Role of TNPO3 in HIV-1 Replication.
- Authors
Diaz-Griffero, Felipe
- Abstract
TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin ß superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction of infection. Here we describe and discuss recent findings suggesting that TNPO3 assists HIV-1 replication in the nucleus and in fact that TNPO3 may assist PIC maturation in the nucleus. In addition, the viral determinant for the requirement of TNPO3 in HIV-1 infection is discussed. This paper summarizes the most significant recent discoveries about this important host factor and its role in HIV-1 replication.
- Subjects
KARYOPHERINS; HIV infections; VIRAL replication; DEVELOPMENTAL biology; HUMAN cell membranes; VIRUS diseases
- Publication
Molecular Biology International, 2012, p1
- ISSN
2090-2190
- Publication type
Article
- DOI
10.1155/2012/868597