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- Title
The Newest "Omics"—Metagenomics and Metabolomics—Enter the Battle against the Neglected Tropical Diseases.
- Authors
Preidis, Geoffrey A.; Hotez, Peter J.
- Abstract
Metagenomics and metabolomics are two emerging fields that have the potential to greatly impact the study and treatment of neglected tropical diseases. Metagenomics involves studying entire communities of microbes and their role in health and disease, while metabolomics focuses on analyzing small molecules produced by a system in response to an environmental stimulus. These technologies have already provided insights into various human conditions and shed light on the complex relationship between microbes, host metabolism, and disease. By pairing metagenomic and metabolomic data, researchers can gain new insights into the host-parasite relationship and potentially develop new diagnostics, therapeutics, and prevention strategies for neglected tropical diseases. Metabolomics has shown potential in identifying biomarkers of disease and monitoring disease progression, as well as studying parasite metabolism and drug resistance. However, the field is still in its early stages and there is much to learn, including the role of the intestinal microbiome and nonbacterial microorganisms in metabolism, identifying biomarkers for infection and drug resistance, and exploring the contribution of nutrition to disease pathogenesis. Overall, metabolomics has the potential to greatly impact the field of neglected tropical diseases.
- Subjects
NEGLECTED diseases; METAGENOMICS; METABOLOMICS; MICROBIAL metabolism; HOST-parasite relationships; BURULI ulcer; BACTERIAL wilt diseases
- Publication
PLoS Neglected Tropical Diseases, 2015, Vol 9, Issue 2, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0003382