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- Title
Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use.
- Authors
Kao, Shou‐Yen; Wu, Cheng‐Hsien; Lin, Shu‐Chun; Yap, Soon‐Kiong; Chang, Che‐Shoa; Wong, Yong‐Kie; Chi, Lin‐Yang; Liu, Tsung‐Yun; Kao, Shou-Yen; Wu, Cheng-Hsien; Lin, Shu-Chun; Yap, Soon-Kiong; Chang, Che-Shoa; Wong, Yong-Kie; Chi, Lin-Yang; Liu, Tsung-Yun
- Abstract
<bold>Background: </bold>The importance of the CYP1A1 polymorphisms at exon 7 (Ile/Val) and 3'-untranslated region (3'-UTR) has been controversial in oral squamous cell carcinoma (OSCC) or head and neck SCC (HNSCC) denoting the value of exploring the correlation between these polymorphisms and risk of betel/smoking associated OSCC. It is also important to evaluate the association between CYP1A1 polymorphisms and susceptibility of oral precancerous lesion (OPL) to confirm the findings in OSCC cases.<bold>Methods: </bold>We examined polymorphic prevalence of CYP1A1 at exon 7 (Ile/Val) and 3'-UTR in 106 cases with OSCC, 60 cases with OPL, and 146 controls. DNA isolated from surgical specimens and whole blood was used for PCR-based genotyping.<bold>Results: </bold>The prevalence of the CYP1A1 A/G genotype (Ile/Val) and G/G genotype (Val/Val) in exon 7 of cases with OSCC (79.2 and 7.6%) and OPL (68.3 and 10%) were significantly higher than in controls (53.4 and 1.4%) (P < 0.0001). The novelty of the present study is that we identified the onset age of OSCC in CYP1A1 A/G genotype to be significantly younger than that in A/A genotype (P < 0.01). No significant difference was seen between cases and controls regarding the polymorphisms at 3'-UTR.<bold>Conclusion: </bold>The findings indicate that the individuals with the CYP1A1 exon 7 containing G allele were at increased risk for OSCC and OPL.
- Subjects
GENETIC polymorphisms; SQUAMOUS cell carcinoma
- Publication
Journal of Oral Pathology & Medicine, 2002, Vol 31, Issue 9, p505
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1034/j.1600-0714.2002.00158.x