We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions.
- Authors
Cowan, C. G.; Lamey, P.-J.; Walsh, M.; Irwin, S. T.; Allen, G.; McKenna, K. E.
- Abstract
Two cases of adult linear IgA disease (LAD) with oral and colonic involvement are presented. Oral findings, for both patients, were of widespread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic symptoms preceded oral symptoms in both cases and a number of investigations were undertaken, including routine histological examination, which suggested either lymphocytic colitis or Crohn's disease. Immunofluorescence studies showed linear IgA deposition confined to the distal colon. These cases highlight that large bowel involvement can be a feature of linear IgA disease and for the first time demonstrate IgA deposition at that site.
- Subjects
COLITIS; COLON diseases; IMMUNOGLOBULIN A; IMMUNOGLOBULINS; MOUTH ulcers; CROHN'S disease; BIOPSY; DIFFERENTIAL diagnosis; FLUORESCENT antibody technique; ORAL diseases; SKIN diseases; ULCERS
- Publication
Journal of Oral Pathology & Medicine, 1995, Vol 24, Issue 8, p374
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1995.tb01202.x