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- Title
Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder.
- Authors
Kalmar, Jessica H.; Fei Wang; Spencer, Linda; Edmiston, Erin; Lacadie, Cheryl M.; Martin, Andrés; Constable, R. Todd; Duncan, James S.; Staib, Lawrence H.; Papademetris, Xenophon; Blumberg, Hilary P.
- Abstract
Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BD I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostral anterior cingulate cortex ( p < .05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD.
- Subjects
BIPOLAR disorder; MAGNETIC resonance imaging; DIAGNOSTIC imaging; DISEASES in young adults; PREFRONTAL cortex
- Publication
Journal of the International Neuropsychological Society, 2009, Vol 15, Issue 3, p476
- ISSN
1355-6177
- Publication type
Article
- DOI
10.1017/S1355617709090584