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- Title
A new Zn(II)-cluster coordination polymer: selective detection of Al(III) ion and treatment activity on hypotension after anesthesia by increasing α receptor expression.
- Authors
Qiu, Huan-Rong; Tian, Shou-Yuan; Yue, Zhi-Jie; Xue, Zhao-Jing; Wang, Hai-Xia; Hong, Fang-Xiao
- Abstract
In this research, a novel coordination polymer (CP) based on Zn(II) ions as nodes [Zn2(1,4-NDC)2(py)2(H2O)] (1, py = pyridine and 1,4-NDCH2 = 1,4-naphthalenedicarboxylic acid) has been produced under hydrothermal reaction condition and then structurally characterized. Furthermore, Zn-complex reveals high sensitivity (with the detection limit of 1.97 × 10−6 M) and fast test time for the Al3+ in the water phase through the fluorescence enhancement method which is rare example in the reported Al3+ detection sensors. The compound was designed for hypotension treatment after anesthesia. First of all, the hypotension animal model was constructed; then, the compound's protective was evaluated. The real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed, and the α receptor expression on the vascular endothelial cells was determined. In addition to this, the western blot was also conducted for the α receptor expression assessment.
- Subjects
COORDINATION polymers; VASCULAR endothelial cells; HYPOTENSION; ALUMINUM-zinc alloys; ANESTHESIA; WESTERN immunoblotting
- Publication
Journal of the Iranian Chemical Society, 2021, Vol 18, Issue 4, p785
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-020-02068-w