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- Title
Preoperative Neutrophil-lymphocyte Ratio as a Predictor of Overall Survival in Patients with Localized Renal Cell Carcinoma.
- Authors
Widz, Damian; Mitura, Przemysław; Buraczyński, Paweł; Płaza, Paweł; Bar, Marek; Cabanek, Michał; Nowak, Grzegorz; Ostrowska, Anna; Bar, Krzysztof; Mitura, Przemyslaw; Buraczynski, Pawel; Plaza, Pawel; Cabanek, Michal
- Abstract
<bold>Purpose: </bold>The neutrophil-to-lymphocyte ratio (NLR), as an indicator of the systemic inflammatory response, predicts adverse outcomes in many malignancies. We investigated its prognostic significance in patients with non-metastatic renal cell carcinoma.<bold>Materials and Methods: </bold>We retrospectively evaluated data of 196 consecutive non-metastatic RCC patients who underwent radical or partial nephrectomy between 2010 and 2012 at a single center. Overall survival (OS) was assessed using the Kaplan-Meier method and compared using the log-rank test. We applied univariate and multivariate Cox regression models to evaluate the prognostic value of dichotomized NLR for OS. Results: At a median follow up of 68 months, high NLR (? 2,69) correlated with worse survival outcome (P = .006 in log-rank test) and higher tumor stage (P = .035). Univariate and multivariate analysis identified elevated NLR (P = .039), as well as age (P = .002), high Fuhrmann grade (P = .002) and high pathologic T stage (P < .001), as significantly associated with overall survival.<bold>Conclusion: </bold>In our cohort, an elevated neutrophil-to-lymphocyte ratio is significantly associated with worse OS on univariate and multivariate analysis. Consequently, the NLR is an easily acquired biomarker, which may be useful in pretreatment patient risk stratification.
- Subjects
MULTIVARIATE analysis; TUMOR classification; LOG-rank test; UNIVARIATE analysis; REGRESSION analysis; NEPHRECTOMY; LYMPHOCYTE count; AGE distribution; KIDNEY tumors; LYMPHOCYTES; NEUTROPHILS; PROGNOSIS; RENAL cell carcinoma; PROPORTIONAL hazards models; RETROSPECTIVE studies; RECEIVER operating characteristic curves; PREOPERATIVE period; KAPLAN-Meier estimator
- Publication
Urology Journal, 2020, Vol 17, Issue 1, p30
- ISSN
1735-1308
- Publication type
journal article
- DOI
10.22037/uj.v0i0.4541