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- Title
β-Arrestins 1 and 2 are critical regulators of inflammation.
- Authors
Fan, Hongkuan
- Abstract
β-Arrestins 1 and 2 couple to seven trans-membrane receptors and regulate G protein-dependent signaling, receptor endocytosis and ubiquitylation. Recent studies have uncovered several unanticipated functions of β-arrestins, suggesting that the role of β-arrestins in cell signaling is much broader than originally thought. It is now recognized that β-arrestins can transduce receptor signaling independent of G proteins. The expression of β-arrestins is differentially regulated in immune cells and tissues in response to specific inflammatory stimuli, and β-arrestins are critical regulators of the inflammatory response. This review will focus on β-arrestins in immune cells and the impact of altered expression on the pathogenesis of specific inflammatory diseases. Understanding the role of β-arrestins in inflammation may lead to new strategies to treat inflammatory diseases, such as sepsis, rheumatoid arthritis, asthma, multiple sclerosis, inflammatory bowel disease and atherosclerosis.
- Subjects
ARRESTINS; INFLAMMATION; MEMBRANE proteins; GENETIC regulation; G protein coupled receptors; ENDOCYTOSIS; UBIQUITINATION
- Publication
Innate Immunity, 2014, Vol 20, Issue 5, p451
- ISSN
1753-4259
- Publication type
Article
- DOI
10.1177/1753425913501098