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- Title
Verification and Implementation of HIV Antibody Differentiation Testing to Improve Turnaround Time for the HIV Diagnostic Algorithm.
- Authors
Chambliss, Allison B; Shulman, Ira A
- Abstract
Background Relying on reference laboratories for HIV confirmation testing may lead to delays in treatment and can cause stress for patients who have positive HIV screening results. Objective To internalize HIV-1/HIV-2 antibody differentiation testing within the hospital laboratory. Methods We analytically verified an HIV antibody differentiation immunoassay and subsequently compared result turnaround times (TATs) for HIV antibody differentiation and HIV-1 qualitative RNA in the months before and after the test internalization. Results HIV antibody differentiation was successfully verified. TATs for HIV antibody differentiation and HIV-1 RNA significantly improved, from medians of 40.4 hours and 156.5 hours to medians of 17.7 hours and 56.5 hours, respectively, after the internalization. The 90th-percentile turnaround times declined by 72% and 44%, respectively. Conclusions It is feasible for a hospital laboratory to verify HIV antibody-differentiation testing. Its implementation may considerably improve result TATs for the HIV diagnostic algorithm.
- Subjects
DIAGNOSIS of HIV infections; IMMUNOASSAY; HOSPITAL laboratories; TURNAROUND time; VIRAL antibodies; ALGORITHMS
- Publication
Laboratory Medicine, 2021, Vol 52, Issue 4, p338
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmaa087