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- Title
Molecular Epidemiology of Carbapenem-Resistant Enterobacterales Strains Isolated from Blood Cultures in Antalya, Turkey.
- Authors
Su, Harun Reşid; Turhan, Özge; Daloğlu, Cemile Aylin Erman; Öğünç, Meral Dilara; Özhak, Betil; Öngüt, Gözde; Kuşkucu, Mert Ahmet; Midilli, Kenan; Mamıkoğlu, Latife
- Abstract
Objective The aim of this study was to investigate the prevalence of carbapenemase and CTX-M genes among 330 blood culture isolates of Enterobacterales with reduced susceptibility to at least 1 carbapenem, between 2010 and 2015. Methods BD Max CRE assay and in-house PCR were used to detect carbapenemase and CTX-M genes. Results At least 1 carbapenemase gene was detected among 113 (74.3%) of the 152 carbapenem resistant isolates. The OXA-48 (69.7%) was the most common carbapenemase followed by VIM, NDM and IMP, whereas no tested isolates were KPC-positive. Eighty-six isolates (56.6%) had CTX-M and 65 had both OXA-48 and CTX-M. Carbapenemase production in Enterobacterales was significantly increased in years (P <.05). Conclusion Our study indicates that there is ongoing endemic circulation of the OXA-48 producing organism in our facility. It is noteworthy that more than half of the OXA-48 producing strains also produced CTX-M enzyme.
- Subjects
TURKEY; BLOOD; CELL culture; CHI-squared test; STATISTICAL correlation; DISEASE susceptibility; FISHER exact test; MOLECULAR epidemiology; POLYMERASE chain reaction; RESEARCH funding; DATA analysis; SYMPTOMS; DATA analysis software
- Publication
Laboratory Medicine, 2020, Vol 51, Issue 6, p601
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmaa017