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- Title
Long-Term Alternating Fasting Increases Interleukin-13 in the Gerbil Hippocampus, But Does Not Protect BBB and Pyramidal Neurons From Ischemia–Reperfusion Injury.
- Authors
Lee, Tae-Kyeong; Park, Yoonsoo; Kim, Bora; Lee, Jae-Chul; Shin, Myoung Cheol; Ohk, Taek Geun; Park, Chan Woo; Cho, Jun Hwi; Park, Joon Ha; Lee, Choong Hyun; Won, Moo-Ho; Ahn, Ji Hyeon
- Abstract
It is questionable whether intermittent fasting (IF) protects against brain ischemic injury. This study examined whether IF increased anti-inflammatory cytokines and protected neurons from ischemia–reperfusion injury in the gerbil hippocampus. Gerbils were subjected to 1-day alternating fasting as IF for 1, 2, or 3 months and assigned to sham or 5 min of transient ischemia. We examined the changes in anti-inflammatory cytokines (IL-4 and IL-13), neurons and IgG by immunohistochemistry or immunofluorescence staining in the cornu ammonis 1 (CA1) region of the hippocampus before and after ischemia. IF increased IL-13 immunoreactivity in the CA1 region before ischemia, but did not affect IL-4 immunoreactivity. After ischemia, IL-13 and 4 immunoreactivities in the CA1 region were significantly lower in IF gerbils than in non-IF gerbils. In the IF gerbils, the CA1 pyramidal neurons were not protected from ischemic injury; in these gerbils, strong IgG immunoreactivity was seen in the CA1 parenchyma, indicating leakage of the BBB. In brief, IF increased IL-13 in the CA1 region, but these neurons were not protected from transient ischemic injury evidenced by IgG immunoreactivity in the CA1 parenchyma. This study indicates that IF increased some anti-inflammatory cytokines but did not afford neuroprotection against ischemic insults via BBB disruption.
- Subjects
GERBILS; INTERLEUKIN-13; HIPPOCAMPUS (Brain); IMMUNOGLOBULIN G; INTERMITTENT fasting; BRAIN injuries
- Publication
Neurochemical Research, 2020, Vol 45, Issue 10, p2352
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-020-03094-z