We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Acupuncture on Glycometabolic Enzymes in Multi-infarct Dementia Rats.
- Authors
Zhao, Lan; Shen, Peng; Han, Yingying; Zhang, Xuezhu; Nie, Kun; Cheng, Haiyan; Kan, Bohong; Li, Guomin; Yu, Jianchun; Han, Jingxian
- Abstract
upuncture has exhibited therapeutic effects on vascular dementia in our previous research. The mechanism of its anti-dementia effects involves energy metabolism. For brain cells, glucose metabolism is almost the only source of energy, and glucose metabolism disorders are early signs of dementia. In addition, glucose metabolism associates closely with glycometabolic enzymes, thereby maintains normal energy supply in brains and neurological and mental activities. In order to investigate its anti-dementia mechanism, we studied the effects of acupuncture on behavior of multi-infarct dementia (MID) rats and glycometabolic enzymes protein expression and activities in their brains. Results showed acupuncture improved the cognitive disorder, and increased the activities of hexokinase, pyruvate kinase, and glucose 6 phosphate dehydrogenase. Accordingly, it suggests that the anti-dementia effects of acupuncture may be mediated by up regulation of hexokinase, pyruvate kinase, and glucose 6 phosphate dehydrogenase activities, influencing energy metabolic system and thus overcoming the dysfunctional cognition of MID.
- Subjects
ACUPUNCTURE; MULTI-infarct dementia; ENZYMES; LABORATORY rats; GLUCOKINASE; PYRUVATE kinase; DEHYDROGENASES; RAT diseases
- Publication
Neurochemical Research, 2011, Vol 36, Issue 5, p693
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-010-0378-x