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- Title
Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply.
- Authors
Linfeng Xu; Xuefeng Qiu; Yanting Zhang; Kai Cao; Xiaozhi Zhao; Jinhui Wu; Yiqiao Hu; Hongqian Guo; Xu, Linfeng; Qiu, Xuefeng; Zhang, Yanting; Cao, Kai; Zhao, Xiaozhi; Wu, Jinhui; Hu, Yiqiao; Guo, Hongqian
- Abstract
<bold>Background: </bold>To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].<bold>Methods: </bold>After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy.<bold>Results: </bold>Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction.<bold>Conclusions: </bold>Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
- Subjects
LIPOSOMES; BILAYER lipid membranes; RADIOTHERAPY; TUMORS; X-ray imaging
- Publication
Journal of Translational Medicine, 2016, Vol 14, p1
- ISSN
1479-5876
- Publication type
journal article
- DOI
10.1186/s12967-016-1033-3